Cell therapy projects



Development of novel cell based therapies

In this project we are studying the potential of Natural Killers (NK) for cancer immunotherapy. So far T cells have been the mainstay of cancer immunotherapy; however, it is generally recognized that NK cells also play an essential role in antitumor immunity. NK cells were certainly recognized as main immune effector cells in the prevention of metastases through the elimination of circulating cancer stem cells with a high metastatic potential. Moreover, as solid tumors have a propensity to particularly down-regulate MHC-I, NK cells provide a failsafe mechanism in these circumstances where cytotoxic T cells, which depend on MHC-I for tumor recognition and elimination, are debilitated. Besides, allogenic NK are well tolerated without Graft-versus-host disease.